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The Latest: Pope departs Rome for trip to Cuba, US

  • A man pushes his motorcycle as people walk on the freshly painted Reina Street on the route that Pope Francis will ride on his popemobile in Havana, Cuba, Saturday, Sept. 19, 2015. Pope Francis begins a 10-day trip to Cuba and the United States on Saturday, embarking on his first trip to the onetime Cold War foes after helping to nudge forward their historic rapprochement.(AP Photo/Desmond Boylan)

    A man pushes his motorcycle as people walk on the freshly painted Reina Street on the route that Pope Francis will ride on his popemobile in Havana, Cuba, Saturday, Sept. 19, 2015. Pope Francis begins a 10-day trip to Cuba and the United States on Saturday, embarking on his first trip to the onetime Cold War foes after helping to nudge forward their historic rapprochement.(AP Photo/Desmond Boylan)  (The Associated Press)

  • A woman prays in the Sagrado Corazon Church in Havana, Cuba, Saturday, Sept. 19, 2015. Pope Francis begins a 10-day trip to Cuba and the United States on Saturday, embarking on his first trip to the onetime Cold War foes after helping to nudge forward their historic rapprochement.(AP Photo/Desmond Boylan)

    A woman prays in the Sagrado Corazon Church in Havana, Cuba, Saturday, Sept. 19, 2015. Pope Francis begins a 10-day trip to Cuba and the United States on Saturday, embarking on his first trip to the onetime Cold War foes after helping to nudge forward their historic rapprochement.(AP Photo/Desmond Boylan)  (The Associated Press)

  • A nun waits with others for Pope Francis to arrive outside the Apostolic Nunciature in Havana, Cuba, Saturday, Sept. 19, 2015. Pope Francis begins a 10-day trip to Cuba and the United States on Saturday, embarking on his first trip to the onetime Cold War foes after helping to nudge forward their historic rapprochement.  (AP Photo/Alessandra Tarantino)

    A nun waits with others for Pope Francis to arrive outside the Apostolic Nunciature in Havana, Cuba, Saturday, Sept. 19, 2015. Pope Francis begins a 10-day trip to Cuba and the United States on Saturday, embarking on his first trip to the onetime Cold War foes after helping to nudge forward their historic rapprochement. (AP Photo/Alessandra Tarantino)  (The Associated Press)

The latest developments in Pope Francis' visit to Cuba and the United States. All times local (EDT):

4:50 a.m.

Pope Francis has departed for Cuba, starting a 10-day pilgrimage that will also take him to the United States.

The special Alitalia flight flying the pope and his entourage took off from Rome's Leonardo da Vinci airport shortly after 10:30 a.m. (0830 GMT) Saturday. Following Cuba, Francis will visit three U.S. cities: Washington, D.C., New York and Philadelphia.