The latest developments in Pope Francis' visit to Cuba and the United States. All times local (EDT):

4:50 a.m.

Pope Francis has departed for Cuba, starting a 10-day pilgrimage that will also take him to the United States.

The special Alitalia flight flying the pope and his entourage took off from Rome's Leonardo da Vinci airport shortly after 10:30 a.m. (0830 GMT) Saturday. Following Cuba, Francis will visit three U.S. cities: Washington, D.C., New York and Philadelphia.