Updated

The European Union is taking steps to increase sanctions against Russia over what many believe is a planned annexation of Ukraine's Crimea region, as Moscow has changed from a wary partner to a diplomatic adversary in the space of a few months.

Sunday's referendum in Crimea on secession has been called illegal by the EU and the U.S., and EU foreign ministers will decide on Monday whether to impose asset freeze and visa sanctions and, if so, who to target.

EU diplomats were working feverishly over the weekend to set up a list of Russian and Moscow-leaning officials from Ukraine who have been involved in pushing for the southern peninsula's secession and possible annexation. Diplomats said member states arrived at weekend talks with different suggestions, so a common list could be drawn up for Monday's meeting of the 28 foreign ministers to make a final decision.

"There must be a firm and united response" at the meeting, said British Foreign Secretary William Hague. "The time has come for tougher restrictive measures to be adopted."

They would likely include military officials who ordered Ukrainian troops to leave their barracks in Crimea and others who were responsible for breakaway actions there. On the other hand, diplomats said they would shy away from economic operators at the moment.

Depending on developments in Moscow and Ukraine, further sanctions could follow during a two-day summit of EU leaders starting on Thursday.

"We will be — I am quite certain — ready for Monday morning. This will be discussed by ministers in order to reach a decision on that second stage of sanctions," a senior EU diplomat said on condition of anonymity because of the sensitivity of the issue.

An EU summit last week suspended talks with Russia on a wide-ranging economic pact and a visa agreement.

On top of that, the EU could move quickly, possibly within a week, to sign the political chapters of a far-reaching association agreement with the provisional government in Kiev, underscoring its support for the new Ukraine government.

EU diplomats in several capitals made it clear the West is unwilling to give up Crimea in the hope of preventing Moscow from moving into eastern Ukraine.

If Moscow takes further measures to acerbate the crisis, the EU leaders already have threatened what they have called "far-reaching consequences for relations in a broad range of economic areas."

It would set off a tit-for-tat game of sanctions, which the EU hopes would increasingly isolate Russia on the global stage. Moscow says it is convinced economic sanctions would hurt the EU as much as Russia itself.

Bound by tens of billions of dollars in trade, there is plenty to hurt one another.

Russia is the EU's third-largest trading partner, mainly because of oil and gas imports, with the EU being its biggest gas consumer. Germany, for example, gets 35 percent of its supplies from Russia.

Russia, in turn, buys everything from machinery to cars from Europe, its biggest trading partner, with exports to Russia totaling 123 billion euros ($170 billion) in 2012.

The big change in relations came when Ukraine's Moscow-leaning president, Viktor Yanukovych, made a last-minute decision to abandon an agreement to strengthen ties with the EU and instead sought closer cooperation with Russia. The EU accused Moscow of pressuring Ukraine to make the change and relations have fallen ever further from then on.

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Jamey Keaten from Paris and Juergen Baetz from Berlin contributed to this story.

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Follow Raf Casert on Twitter at http://www.twitter.com/rcasert