A Polish TV interviewer asked on Saturday how she manages juggling being secretary of state and mother of the bride.
Clinton agreed that both are "serious, important and stressful."
"Luckily we have e-mail now. I can communicate and people can send me pictures of flower arrangements or other kinds of decisions," she told the Polish current affairs program Tomasz Lis Live.
"It's a very happy time for my family. ... It truly is the most important thing in my life right now," Clinton said about her daughter's upcoming wedding.
The Associated Press has reported that Chelsea Clinton's wedding to Marc Mezvinsky will take place July 31 in Rhinebeck, N.Y., about two hours north of New York City.
Chelsea Clinton, 30, is a graduate student at Columbia University's School of Public Health. Mezvinsky, 32, is an investment banker.