Noel Devine ran for a career-high 220 yards and a touchdown, leading West Virginia to a 35-24 victory over Colorado on Thursday night.
Jarrett Brown threw two touchdown passes and redshirt freshman fullback Ryan Clarke ran for two fourth-quarter scores for West Virginia (3-1).
Both offenses played sloppily despite having an extra week to prepare. West Virginia lost four fumbles and intercepted three of Cody Hawkins' passes.
Hawkins threw two touchdown passes, but Colorado (1-3) managed three total points on four other drives that went inside the 30.
Colorado now faces the impossible task of meeting coach Dan Hawkins' offseason directive of "10 wins, no excuses." The Buffaloes would have to win the remainder of their games, including a bowl, starting next week at No. 2 Texas.
Colorado was outgained 405-392 after shutting out Wyoming 24-0 on Sept. 19.
The Buffaloes kept Brown mostly in check, but couldn't match Devine's speed.
Devine went 77 yards for a score on West Virginia's second play from scrimmage and ran 56 yards late in the second quarter that set up Brown's 6-yard scoring pass to Jock Sanders. Devine ran nine times during a 14-play drive midway through the fourth quarter that ended in Clarke's 1-yard TD run for a 28-17 lead.
After Colorado turned the ball over on downs deep in its own territory, Clarke tacked on an 8-yard scoring run to put the game out of reach.
Brown, sixth in the nation in total offense at 335 yards per game, twice overthrew wide-open receivers far downfield and finished 12 of 19 for just 148 yards. He was sacked three times.
Colorado's Rodney Stewart had another solid game against the Mountaineers. Last year he rushed for 166 yards, the most ever by a Colorado freshman. On Thursday, Stewart had a 36-yard TD run in the first quarter and finished with 105 yards on 21 carries.
Cody Hawkins kept his cool at times, avoiding the blitz to hit Scotty McKnight with a 29-yard scoring toss on fourth-and-7 early in the third that cut Colorado's deficit to four at 21-17. But Colorado didn't score again until the final seconds of the game.
Hawkins went 27 of 52 for 292 yards. Riar Geer caught eight passes for 113 yards.