Ishmael Smith and C.J. Harris scored 16 points apiece to help Wake Forest cruised to 76-52 win over Winston-Salem State on Tuesday night.
Al-Farouq Aminu and Ari Stewart added 13 points each for the Demon Deacons (4-0), who led by as many as 29 points in the second half in beating their smaller in-city rival for the fourth straight year.
Brian Fisher scored 12 points and Andrew Jackson added 11 for the Rams (1-4), who shot just 32.2 percent from the field.
Wake Forest shot 52.6 percent and used its size advantage inside to outscore Winston-Salem State 44-18 in the paint.
Still, the Rams hung with their bigger rival through the first 7 minutes of the first half, leading twice and tying the score twice. But Winston-Salem State would falter, shooting just 26.5 percent in the half, and Wake Forest pulled ahead to lead by as many as 17 points.