Manny Ramirez hit two two-run homers, giving him 524 for his career, and the Los Angeles Dodgers beat the San Diego Padres 7-2 on Wednesday night.

The Dodgers, who have won 10 of 11, extended their lead in the NL West to a season-high 3 1/2 games over Arizona, which lost to San Francisco 4-3.

Derek Lowe (13-11) allowed three hits and one run in 5 1-3 innings before leaving the game in the sixth after being hit on the right leg by a one-hopper by Kevin Kouzmanoff.

Ramirez' first homer came in the fifth off starter Shawn Estes (2-2). His second homer came off Dirk Hayhurst in the ninth. Ramirez has 34 homers this season, 14 with the Dodgers.

James Loney homered for the Dodgers, hitting his 12th to ignite a three-run second inning. The homer was his first extra base hit in 13 games. Blake DeWitt's RBI double and Russell Martin's RBI single produced the other runs.

The Padres scored in the first on a leadoff double by Brian Giales and two infield grounders, the second by Kouzmanoff that drove in a run.

That run snapped Lowe's 19 consecutive scoreless innings streak.

Lowe appeared to hurt his right knee when he was hit by the grounder with one out in the sixth. He threw a couple of warmup pitches before leaving. He was relieved by Scott Elbert, who finished the inning

Dodgers right-hander Brad Penny, who was activated off the 15-day disabled list (right shoulder inflammation) earlier Wednesday came on to start the seventh. He didn't get an out as he walked the leadoff batter Will Venable and gave up singles to Josh Bard and Matt Antonelli.

Cory Wade came on for the Dodgers and after giving up a sacrifice fly to pinch-hitter Drew Macias, who got his first major league RBI, got Giles to hit into an inning-ending double play.

Notes:@ Dodgers SS Rafael Furcal, who has been on the DL since May 6 before having lower back surgery, was one of the hitters to face Takashi Saito in a simulated game Wednesday. Dodgers manager Joe Torre said he is hopeful Furcal could return before the end of the regular season. ... Joe Beimel extended his Dodgers record when he pitched in his 96th consecutive game without allowing a home run. ... Padres reliever Mike Ekstrom made his major league debut Wednesday and pitched two scoreless innings.

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