Sam Bradford overcame two interceptions and threw for a career-best 395 yards and five touchdowns and No. 4 Oklahoma overpowered Cincinnati 52-26 Saturday.

Freshman Ryan Broyles had a breakout game with 141 receiving yards, Jermaine Gresham caught two touchdown passes and the Sooners extended the nation's longest home winning streak to 20 games.

Broyles had a 27-yard touchdown reception in the first quarter and extended a key second-half drive with a leaping 43-yard catch to allow the Sooners (2-0) to start pulling away with 24 consecutive points.

For Bradford, who led the nation in quarterback rating last season, it was the third time he tied the school record for TD passes held by 2003 Heisman Trophy winner Jason White and 2000 Heisman runner-up Josh Heupel. His only other two-interception game came in an upset loss last season at Colorado.

Cincinnati's Mardy Gilyard returned a kickoff 97 yards for a touchdown to break one of the longest runback droughts in college football. The last score by the Bearcats (1-1) on a kickoff return came in 1995, and only two schools have gone longer than Cincinnati's 145 games without one.

Gilyard finished with a school-record 365 all purpose yards, including 119 yards receiving on seven first-half catches.

Cincinnati's turnover-happy defense kept it close for a while, clamping down after allowing the Sooners to get off to a 14-0 start.

The Bearcats (1-1), who led the nation last season with 26 interceptions, got interceptions from Brad Jones and Ohio State transfer Brandon Underwood. Both led to touchdowns to get Cincinnati back within 21-13.

It was 28-20 after Gilyard's runback in the third quarter, but DeMarco Murray went untouched on an 11-yard touchdown run and then Cincinnati coach Brian Kelly's bag of tricks backfired. He'd already run a failed Statue of Liberty play _ reminiscent of Boise State's Fiesta Bowl win in 2007 against Oklahoma _ near the goal line and a botched wide receiver pass when J.R. Bryant jumped to bat down punter Kevin Huber's pass on a fake.

Bradford hit Gresham across the middle on the next play, and the 6-foot-6 tight end bullied through a defender on his way in for a 23-yard score and a 42-20 Oklahoma lead.

The Bearcats lost quarterback Dustin Grutza two drives later to an apparent leg injury. He was wheeled off in a cart after being sacked by three Oklahoma players. Grutza went 19-for-29 for 218 yards, throwing for one touchdown and running for another on a 1-yard sneak.

He also had one interception, ending a promising Bearcats drive on first-and-goal from the 6-yard line.

Broyles, who was making his debut after serving a one-game suspension in the opener, set the Sooners' freshman record with his receiving total and was an impact player from the start. He picked up 31 yards with some nifty footwork up the sideline after his first career catch, and he finished the Sooners' opening drive with a 27-yard TD grab on the next play.

He bailed out Bradford on a third-and-9 play with the Sooners leading only 28-20 in the third quarter, jumping between two defenders for a 43-yard catch along the right sideline.

Four plays later, Bradford extended the drive again with a successful sneak on fourth-and-inches, and Murray finished the drive with his scamper up the middle.

The home winning streak, which started after TCU snapped the Sooners' 19-game stretch in the 2005 opener, is the third-longest in school history and the first that long since a 20-game stretch that lasted from 1976 to 1980.

(This version CORRECTS No. 4 Oklahoma 52, Cincinnati 26; corrects to 5 TDs, sted 4, in overline. Optional to follow.)

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