Storms are likely to turn severe from northwestern Texas to southern Wisconsin and threaten outdoor activities and travel on Saturday.
The greatest risk to people outdoors will be from lightning strikes.
People on the road or partaking in outdoor activities such as golf, softball, fishing or Easter egg hunts should keep an eye out for rapidly changing weather conditions.
"The storms will have the potential to cause flash flooding, damaging wind gusts and hail," according to AccuWeather Lead Storm Warning Meteorologist Eddie Walker.
Some of the storms from Missouri and Kansas on south could produce hail the size of golf balls or larger.
"Because of the way the atmosphere will be set up, an outbreak of tornadoes is not likely in this case," Walker said.
However, with any severe thunderstorm event, there is the possibility of a couple of brief, isolated tornadoes.
Cities that could be hit by a heavy, gusty or severe thunderstorm include Kansas City, Missouri; Wichita, Kansas; Davenport, Iowa; Madison, Wisconsin; Moline, Illinois; Cedar Rapids, Iowa; and Enid, Oklahoma.
The thunderstorms will drift eastward and can remain locally strong and drenching well into Saturday night. Some people may be awakened by a torrential downpour with thunder and lightning in cities such as Chicago, St. Louis and Oklahoma City.
Thunderstorms are likely to regenerate and can become locally heavy and gusty from parts of the southern Plains to the Midwest and interior Northeast on Easter Sunday.