Rounds of showers and thunderstorms will bring the potential for flash flooding and localized damaging wind gusts through Thursday.
Those from central Kansas to Ohio will need to stay alert for rapidly changing weather conditions.
"The main threats with these storms will be dangerous lightning, heavy downpours and strong wind gusts," AccuWeather Meteorologist Dan Pydynowski said.
The threat on Wednesday will focus on the corridor from Kansas City, Missouri, to Chicago. A few gusty thunderstorms could approach Grand Rapids, Michigan, a town still cleaning up from a tornado this past weekend.
These storms could delay travel on the road and in the air. Winds may be strong enough to knock down trees and power lines, leading to sporadic power outages.
Where thunderstorms repeat, the potential for flash flooding will be greatest.
Drivers are urged to slow down in any heavy downpour to reduce the risk of hydroplaning. Never drive through a flooded roadway.
The threat will shift slightly south on Thursday.
"Oklahoma City, St. Louis, Indianapolis and Columbus, Ohio, may face some of these storms on Thursday," Pydynowski said.
These storms will depart the area on Friday as they shift toward the Northeast.