LIVE: Developing blizzard cuts power to 50,000 in Denver area

A blizzard is on pace to bring significant travel problems to the central United States.

The heaviest snow will fall from eastern Colorado into Nebraska on Wednesday, including in Denver. The snow will then shift eastward into portions of the Upper Midwest into Thursday, including cities of Sioux Falls, South Dakota, Minneapolis, and Green Bay, Wisconsin.

Strong winds will accompany this storm and could lead to whiteout conditions at times from Colorado to Wisconsin. Over a foot of snow could fall in some locations.

"While some of the snow will melt as it falls on paved areas during the daytime, where it snows hard, roads will become slushy and then snow-covered," AccuWeather Meteorologist Steve Travis said.

UPDATES: (All times are listed in Mountain Daylight Time)

8:35 a.m. MDT Wednesday: All northbound lanes of I-225 are closed at the I-70 intersection in Denver due to a jack-knifed truck, police report.

8:32 a.m. MDT Wednesday: Snowy roads made for slippery travel in Denver this morning:

8:21 a.m. MDT Wednesday: More than 12 inches of snow was reported in Boulder County, Colorado, according to a NWS trained spotter.

8:14 a.m. MDT Wednesday: Heavy snow pulled tree branches down in Fort Collins, Colorado, this morning:

8:11 a.m. MDT Wednesday: Visibility is down to 10 feet in the Cheyenne, Wyoming, area as snow continues to fall amid strong winds, according to a NWS employee.

7:56 a.m. MDT Wednesday: A crash on I-80 near Evanston, Wyoming, near the Utah border, has closed all westbound lanes, according to officials.

7:49 a.m. MDT Wednesday: Thundersnow was reported near Limon, Colorado.

7:47 a.m. MDT Wednesday: Snow is covering the ground in Fort Collins, Colorado:

7:42 a.m. MDT Wednesday: According to emergency management, fire trucks are getting stuck on snowy roads in the Cheyenne, Wyoming, area. All highways in the area are closed.

7:39 a.m. MDT Wednesday: Snow continues to fall in Fort Collins, Colorado:

7:35 a.m. MDT Wednesday: More than 55,000 Xcel Energy customers are without power from Denver to Fort Collins, Colorado, the utility reports.

7:15 a.m. MDT Wednesday: Snow is piling up in Fort Collins, Colorado:

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7:02 a.m. MDT Wednesday: Snowcovered roads are making for hazardous travel in Highlands Ranch, Colorado:

6:53 a.m. MDT Wednesday: Portions of Interstate 25 and I-80 are closed in the Cheyenne, Wyoming, area due to heavy snow and multiple accidents, according to the Wyoming Department of Transportation.

6:48 a.m. MDT Wednesday: Snow is accumulating in Fort Collins, Colorado:

6:30 a.m. MDT Wednesday: More than 30,000 Xcel Energy customers are without power in the Denver area, the utility reports.

6:27 a.m. MDT Wednesday: Boulder County offices are closed today due to the storm.

6:08 a.m. MDT Wednesday: Airport officials are urging travelers to allow ample time in the Denver area:

5:28 a.m. MDT Wednesday: Strong winds are accompanying the snow in Loveland, Colorado:

5:23 a.m. MDT Wednesday: Denver Public Schools and Aurora Public Schools are canceled for Wednesday due to the impending snow.

5:13 a.m. MDT Wednesday: Snow is accumulating in Denver neighborhoods:

4:55 a.m. MDT Wednesday: More than 200 flights have been canceled at Denver International Airport, according to FlightStats.

4:51 a.m. MDT Wednesday: Snow has been falling at a rate of 2 inches an hour in parts of the Denver area, the NWS reports.