Blizzard conditions will hamper travel from the Rockies into the Upper Midwest through Tuesday.
The storm will cause disruptive travel on major highways including interstates 25, 29, 35, 40, 70, 80, 90 and 94. Air travel will also be a major problem throughout the region.
Snowfall rates will be 1 inch an hour and strong winds will create blowing, drifting and visibility near zero. Travel will be extremely difficult if not impossible and more road closures are likely overnight.
"Heavy thunderstorms will also move through the southern Plains overnight and some can become severe across parts of Oklahoma, Texas and Arkansas," AccuWeather Meteorologist Mike Doll said. "Heavy rain, damaging winds, hail and an isolated tornado are all possible."
UPDATES: (All times are listed in CST)
10:35 p.m. CST Monday: I-225 is snow-covered north of Aurora, Colorado, CDOT webcam shows.
10:33 p.m. CST Monday: Snowy travel on I-25 in Denver.
Light traffic on I-25 at the Downing Street Bridge, snow is falling. #cowx pic.twitter.com/vT2pUJvRX7— Alan Stedman (@AlanStedman7) February 2, 2016
10:28 p.m. CST Monday: Wyoming closes I-80 from Cheyenne to Laramie due to winter conditions.
As of 9:00PM, be advised I80 btwn Cheyenne & Laramie is expected to be closed for an extended period of time. Opening time unknown. #wyoroad— Wyoming DOT (@WYDOT_I80) February 2, 2016
10:17 p.m. CST Monday: 15.1 inches of snow have fallen 4 miles north-northeast of Colorado Springs, according to NWS-trained spotter.
10:15 p.m. CST Monday: Snowy travel conditions reported in northwest Kansas, according to Kansas Department of Transportation.
10:12 p.m. CST Monday: U.S. Route 287 is closed at Jeffrey City, Wyoming, WYDOT said.
10:00 p.m. CST Monday: I-80 closed from Laramie to Cheyenne, Wyoming, WYDOT reports.
I80: Closed BOTH DIR due to winter conditions between Laramie and Cheyenne. 01-FEB 20:42— Wyoming DOT (@WYDOT_Southeast) February 2, 2016
9:57 p.m. CST Monday: Interstate 70 closed in parts of Colorado.
I-70 closed both directions from Airpark to KS border b/c white out conditions— CDOT (@ColoradoDOT) February 2, 2016