Shortly after liftoff, a commercial rocket carrying more than 5,000 pounds of science experiments and equipment to the International Space Station exploded at the launch site on Wallops Island, Virginia.
"No injuries were reported following the first catastrophic launch in NASA's commercial spaceflight effort," the Associated Press reported.
Flames from the Orbital Sciences Corp.'s Antares rocket could be seen across the launch site.
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Watch the catastrophic failure of the spacecraft here:
With winds blowing from the southwest toward Chincoteague Island, which is only a few miles from the launch area, it's possible smoke will reach the area.
"It's not a strong wind, but it's going to be steady all night," AccuWeather.com Meteorologist Dave Samuhel said, adding the wind speed was around 10-15 mph.