Most of the storm will be rain from St. Louis to Chicago, Indianapolis and Detroit, although some wet snowflakes may be mixed in as the rain ends.
In these areas, the combination of the rain, melting snow and ice jams will be enough to cause flooding in some areas.
Despite the warmer air moving in, enough cold air will remain to allow snow and ice to develop across portions of the Upper Midwest, including Madison and Green Bay, Wis., Des Moines, Iowa, and Rochester, Minn.
The wintry precipitation may lead to slippery travel along Interstates 35, 80, 90 and 94, especially Friday night.
While Minneapolis may briefly get brushed with a period of snow that could cause slick travel, most of the snow should stay to the south and east of the city.
While major snow and ice accumulations are not anticipated, it does not take much snow or ice to create hazardous road conditions.
For most of the region, the wintry mix will move out by Saturday morning, allowing travel to improve fairly quickly as temperatures rise up above freezing by the afternoon in most locations.
Across the Upper Peninsula of Michigan, the snow may persist into the afternoon hours.
A storm system developing across the central Plains on Friday will be responsible for dragging the milder air into much of the eastern third of the nation.
As the storm tracks into the Great Lakes, enough cold air will remain to allow for a narrow area that can see an accumulation of snow on the northwest side of the system.
As the storm pulls away, the air moving in behind it will not be all that cold, especially after the recent stretch of brutal cold. Temperatures over the weekend across most of the Midwest will be 5 to 10 degrees above average.
A brief shot of colder air appears poised to arrive early next week, although it will not pack the extreme punch that the last cold snap did.