A storm will spread a zone of snow and wintry mix from southeastern Nebraska to northern Arkansas spanning late Wednesday night, Thursday and into Thursday night.
The storm system will track from northwest to southeast across the area and is likely to dive south of St. Louis.
In some areas, the snow can be heavy for several hours and could lead to slippery roads and travel delays.
Cities in the path of the snow and/or wintry mix include Kansas City, Springfield, Branson and St. Joseph, Mo., as well as Topeka and Salina, Kan., and Mountain Home and Jonesboro, Ark.
A general swath of 1- to 3- inch snowfall is forecast in this area with road conditions ranging from wet to slushy. However, a narrow band of much heavier snow is possible. A few locations could pick up a half a foot or more with snowcovered roads, and this may not be limited to the higher ground in the Ozarks.
Rain is the most likely form of precipitation in Little Rock and Memphis by the time the system rolls in later Thursday and Thursday night. However, some wet snow could mix in for a time. Thunder is also possible in these areas. Locally strong thunderstorms are possible farther south, where it is warmer.
The system will go on to produce another dose of drenching rain over the interior South Friday.
A much larger storm system will take aim over the central and southern Plains to the middle and lower Mississippi Valley this weekend.
Part of the same area that receive snow from the Thursday system could be hit with even heavier snow Saturday into Sunday. Some areas that are missed by the Thursday snow in the region could be targeted. It is possible St. Louis gets into the snow on Sunday.
The weekend storm also bring the risk of flooding and severe thunderstorms in the South.