Dorothy "Dottie" Thomas, the research partner and wife of the Nobel laureate who pioneered the bone marrow transplant, has died in her Seattle-area home at 92.

Her death Friday was announced by the Fred Hutchinson Cancer Research Center in Seattle. Her husband, the late Dr. E. Donnall Thomas, had directed its clinical research division.

Dottie Thomas was known as "the mother of bone marrow transplantation" because of the years she spent working with her husband.

The center says the couple worked as a team and proved that bone marrow transplantation could treat leukemia and other blood cancers.

Fred Hutchinson president Dr. Gary Gilliland said in a statement that Dottie Thomas had a profound impact on numerous patients, and that she and her husband were amazing together.