Updated

Three people were killed and two others injured when a helicopter and a small airplane collided near an airport in Frederick, Md. on Thursday afternoon.

The mid-air crash occurred around 3:40 p.m. within a half-mile of Frederick Municipal Airport, Frederick County Division of Fire Rescue Services Capt. Kevin Fox told FoxNews.com. No one was injured on the ground, he said.

It was not immediately clear what caused the collision, he added. Maryland State Police are investigating, and the FAA and National Transportation Safety Board have been notified, Fox said.

The two survivors were rushed to Meritus Medical Center in nearby Hagerstown. Fox did not know their conditions.

Aerial footage from WTTG-TV in Washington showed aircraft wreckage in a stand of trees.

The airport opened in 1948. It has two runways.

Nurse Nina Pham arrived at the airport last week from Dallas on her way to treatment for Ebola at the National Institutes of Health in Bethesda, Md.

FoxNews.com's Karl de Vries and The Associated Press contributed to this report.