The agency took out a full-page ad in the April edition of Plastic Surgery News, featuring photos of Bulger's girlfriend, Catherine Greig. The FBI says the 59-year-old Greig had multiple cosmetic procedures before she allegedly went on the lam with Bulger in 1995, including breast implants, a nose job and a face lift.
The ad asks plastic surgeons, "Have you treated this woman?"
The newsletter is circulated to more than 6,000 plastic surgeons around the world.
Bulger is wanted for 19 murders and is on the FBI's 10 Most Wanted list with a $2 million reward for information leading to his capture.
Allure magazine first reported on the FBI's ad.
The last confirmed Bulger sighting was in London in 2002.