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Alzheimer's Antibodies

Pfizer, J&J Alzheimer's drug fails one of four big trials

Pfizer Inc said on Monday that its experimental Alzheimer's disease treatment failed to prove effective in one of four high-stakes late-stage trials in patients with mild to moderate forms of the memory-robbing disease.The trial involved people who carry a variation of a gene called ApoE4 that makes them far more likely to develop Alzheimer's disease. Pfizer said it and its partner Johnson & Johnson would continue with three other late-stage trials of their medicine, called bapineuzumab, based upon a review by independent safety monitors.The drug failed to improve cognitive and life function, the primary goals of the trial, compared with patients taking placebos.Alzheimer's is the most common form of dementia and the sixth leading cause of death in the United States. An estimated 5 million Americans are believed to have the disease. An estimated 36 million people worldwide are believed to have dementia, including Alzheimer's disease, Pfizer said.Morningstar analyst Damien Conover said ...

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  2. Failed Alzheimer's drug may get second chance, experts say

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  3. Alzheimer's drug slows decline in some patients

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  4. Studies: Alzheimer's drug may stabilize brain plaque

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  5. Lilly plans another study for Alzheimer's drug

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  9. Lilly Drug May Slow Memory Loss Among Mild Alzheimer's Sufferers

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  10. FDA outlines path to test Alzheimer's drugs earlier

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  11. Study gives new clues on how Alzheimer's spreads

    Alzheimer's disease appears to spread in a predictable pattern, infecting brain cell after brain cell as the disease spreads along linked circuits known as synapses,...

  12. Skin Patch for Alzheimer's New Way to Deliver Older Drug

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  1. New Theory of Alzheimer's Explains Drug Failures

    Brain plaques, long considered the chief killer of brain cells and the cause of Alzheimer's disease, may actually play a protective role under a new theory that is c...

  2. New Theory of Alzheimer's Explains Drug Failures

    Brain plaques, long considered the chief killer of brain cells and the cause of Alzheimer's disease, may actually play a protective role under a new theory that is c...

  3. Key results for Alzheimer's drugs coming soon

    We're about to find out if there will be a way anytime soon to slow the course of Alzheimer's disease. Results are due within a month or so from key studies of two d...

  4. Drug fails to slow Alzheimer's in large study

    Baxter International Inc. says that a blood product it was testing failed to slow mental decline or to preserve physical function in a major study of 390 patients wi...

  5. Antibodies May Slow Alzheimer's Mental Decline

    An existing treatment for immune disorders shows promise for slowing the memory decline of Alzheimer's disease.The treatment — intravenous immunoglobulin, or IVIG fo...

  6. Drug Gammagard may help stabilize Alzheimer's, small study finds

    For the first time, researchers are reporting that a treatment might help stabilize Alzheimer's disease for as much as three years, but the evidence is weak and only...

  7. Roche 'brain shuttle' technology offers Alzheimer's hope

    Swiss drugmaker Roche has found an efficient way for complex antibody drugs to reach and penetrate the brain, raising the possibility of more effective treatments fo...

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