She was upbeat, friendly, always armed with a smile. Since going missing Tuesday afternoon, Yale University graduate student Annie Le has been sorely missed by all who knew her.

Following the discovery of a female body presumed to be Le in the building at 10 Amistad St. on Sunday evening — the same day Le was to wed her college sweetheart — friends, family and colleagues are mourning her loss.

Described as sweet, spunky and smart, the 24-year-old pharmacology student and Placerville, Calif., native was scheduled to be married Sunday to Jonathan Widawsky, a graduate student at Columbia University whom she met at the University of Rochester.

While working overtime in her Yale laboratory in the weeks leading up to her wedding, Le chatted constantly about her excitement for the ceremony, colleagues said.

“Lucky I’m in love with my best friend :),” Le had written on her Facebook profile. According to status updates and wall posts on the profile, Le and Widawsky were engaged in July of 2008 and celebrated their five-year anniversary as a couple in March of this year.

At Yale, colleagues at Le’s lab said she was dedicated to her research. Recently she had decided on the topic of her dissertation: the study of how certain proteins are involved with metabolic diseases such as diabetes.

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