Madeleine McCann's parents will be interviewed by Oprah Winfrey to mark the second anniversary of their daughter's disappearance.
Kate and Gerry McCann will fly to Chicago next week to film a one-hour special with the talk show queen.
It will be broadcast on May 3, two years after Madeleinevanished from a holiday apartment in Praia da Luz, Portugal.
The show will also feature footage from the National Center for Missing and Exploited Childrenin Washington.
The U.S. charity has produced age-progressed images for the program to show what Madeleine would look like now, at age five.
"These new photos will be revealed for the first time on Oprah," McCann family spokesman, Clarence Mitchell, told Sky News Online. "They have been done with the latest technology and Kate and Gerry believe they are the best possible visualization of what Madeleine looks like now."
Mitchell played down speculation of a multi-million dollar deal for the interview.
"Oprah Winfrey does not pay for interviews," he said.
"Kate and Gerry will not be receiving a single dollar for this and neither will the fund for Madeleine.
"The importance is the global platform it gives them to look for that breakthrough in the search for Madeleine."
Last year he denied the couple were at the center of a bidding war between Winfrey and ABC star Barbara Walters.
Oprahhas been asking the McCanns to appear on the show since disappeared.
But it is understood they thought it was inappropriate while they were still suspects in her disappearance.