The grandparents of murdered Florida toddler Caylee Anthony are set to make an appearance on 'The Oprah Winfrey Show' in May.

The television talk show says Cindy and George Anthony will speak about their granddaughter and the investigation into her death. The interview with Oprah will be their first sit-down interview since Caylee's remains were found in December, six months after she disappeared.

Click here for photos.

The couple's daughter, 23-year-old Casey Anthony, is facing a first-degree murder charge after 2-year-old Caylee's remains were found by a utility worker about a half-mile from the family's home.

Click here to see the videotapes of Casey Anthony in jail.

She claimed that Caylee was kidnapped by a baby sitter, but a month passed before authorities were notified of the girl's disappearance. Her trial is slated to begin in October.

Click here for more on this story from MyFOXOrlando.com.

The Associated Press contributed to this report.