An 18-wheeler exploded in flames on a major interstate Thursday afternoon, injuring at least two people and sending a thick plume of black smoke towering over the area.

It was not immediately clear what caused the explosion.

Click here for more from MyFoxDFW.com.

A call reporting an explosion on northbound Interstate 35 north of Lewisville Lake Bridge came in around 1:40 p.m, said Denton County Sheriff's spokesman Tom Reedy. The truck was fully engulfed in flames and one witness reported a man jumped out of the truck's cab and was on fire, Reedy said.

Traffic was shut down on both sides of Interstate 35E.

Hickory Creek is located about 30 miles northwest of Dallas.