Interstate 95 was shut down in both directions Friday after a fatal accident involving a tanker truck, a tractor trailer and several cars.

A tanker truck may have spilled fuel and a tractor trailer jackknifed and landed on its side, state police said. The accident, which was reported at 10:20 a.m., happened on southbound I-95 between exits 74 and 75.

"It's a significant accident," said Lt. J. Paul Vance, a state police spokesman.

There were confirmed fatalities, but Vance did not know how many. Two people were taken to Lawrence & Memorial Hospital in New London.

Four cars also were involved, WTNH-TV reported.

State transportation officials say the accident would take seven to eight hours to clean up, snarling traffic on a portion of the key interstate highway in the Northeast corridor.

Authorities also shut Interstate 395 from exit 77 south to I-95 and a portion of Route 1.

Firefighters were spraying foam as a precaution in a fuel spill, and state environmental officials were headed to the site. The tanker belongs to Northeast Carriers.

State police and firefighters set up a command post at exit 75 of the highway.