The series, scheduled to debut in late 2007 and described by the cable channel as "hilarious and heartwarming," will show the hip-hop heavyweight trying to balance his different worlds.
"The juggling act that Snoop faces day-in, day-out between career and family is certain to resonate with our viewers," said Ted Harbert, president and CEO of Comcast Entertainment Group, which operates the E! channel.
The rapper, whose real name is Cordozar Calvin Broadus Jr., has three children, is active in community causes and is involved in a youth football league he founded, E! said.
He's also had court-ordered obligations on his plate. In April, he was sentenced to five years' probation and 800 hours of community service after he pleaded no contest to felony gun and drug charges. The charges followed his arrest last year at an airport in Burbank for investigation of transporting marijuana. Police later found a gun at his home.
Also recently, in 2006 he and five other men were arrested on charges of violent disorder and starting a brawl when some in his party were denied entry to British Airways' first-class lounge at Heathrow Airport.
His platinum-selling albums include his most recent, "Tha Blue Carpet Treatment." He's also a producer and actor.