The delicate frescoes of the Renaissance master Lorenzo di Pietro, nicknamed "il Vecchietta," have survived for more than five centuries in the millennium-old Santa Maria della Scala in Siena, Italy, one of the oldest hospitals in Europe.

Ironically, failed conservation efforts to save the frescoes may have destroyed them instead.

But new advanced potions, similar in composition to salad dressing, developed by Italian scientists could help cleanse masterpieces of hundreds of years of grime and reverse the accidental harm wrought by prior restoration and preservation attempts.

• Click here for FOXNews.com's Patents and Innovation Center.

Art, like artists, often suffers from age, especially after long centuries of tarnishing, deluge and flame.

Unfortunately, techniques designed some 50 years ago to conserve works of art have been found to degrade as they age.

In the case of Vecchietta's frescoes, the polyacrylate resin used to conserve the paintings darkened their colors and contributed an unwelcome reflective glare.

Physical chemist Piero Baglioni at the University of Florence and his colleagues first employed salad-dressing-like formulations two decades ago, when they were asked to help remove candle wax from Renaissance paintings in Florentine churches.

Salad dressing is essentially a mix, or emulsion, of oil and water. The micro-emulsions Baglioni and his collaborators used to extract the contaminants from the art were adapted from an emulsion used to pull extra petroleum from oil fields.

Baglioni and his colleagues have invented micro-emulsions that are far better and less toxic than before.

The key is a sugar-like compound that wraps an oily cleanser in tiny droplets less than a tenth of a wavelength of visible light in size.

Altogether, these drops possess a tremendous amount of surface area to clean with, making the micro-emulsion ferocious at scrubbing away grime and polyacrylate resin.

This means far less of the cleanser is needed than before, "so it's much safer, and you won't, say, contaminate an entire church with it," Baglioni told LiveScience.

The researchers first pour the micro-emulsion onto cellulose fibers to make a paste.

They next envelop artwork in super-thin Japanese paper and coat the wrapped-up art with the paste.

After 10 minutes to a few hours, the paste is removed and the painting is cleaned.

So far, Baglioni and his colleagues have used their new micro-emulsion to clean polyacrylate off Vecchietta frescoes.

They also removed tar-like deposits from a 17th century fresco in Florence that was damaged during the 1966 flooding of the Arno River, as detailed in the May 22 issue of the journal Langmuir.

The micro-emulsion will next be used to clean artwork in Sweden later this month.

"We don't charge anything for it," Baglioni said. "We provide it basically for free."

Copyright © 2007 Imaginova Corp. All Rights Reserved. This material may not be published, broadcast, rewritten or redistributed.