Anne Heche and her husband are separating after five years of marriage, her spokeswoman said Wednesday.
"They have requested that they be allowed their privacy at this time," publicist Lisa Kasteler said in a statement.
Heche, 37, and Coleman Laffoon, a motion picture cameraman, were married in September 2001. The couple have a 4-year-old son, Homer.
They met while working on a documentary about Ellen DeGeneres' return to stand-up comedy.
Heche had a high-profile relationship with DeGeneres for more than three years. They announced their separation in August 2000.
Heche plays a relationship guru who relocates to Alaska in the ABC-TV drama "Men in Trees." Her film credits include "Wag the Dog," "John Q" and "Donnie Brasco."