Will Leo beat himself? Will "Borat" be a winner? And of course, "who" will the stars be wearing?
These are only some of the burning questions heading into the 64th Annual Golden Globe Awards, which will air live on NBC Monday from 8 p.m. to 11 p.m. EST.
Jessica Biel, Jennifer Garner, Renee Zellweger, Drew Barrymore, Steve Carell, George Clooney, Hugh Grant, Salma Hayek, Eva Longoria, Jennifer Lopez, Sarah Jessica Parker, Ben Stiller, Justin Timberlake, Cameron Diaz, Reese Witherspoon and the cast of “Heroes" will be among the presenters.
Leonardo DiCaprio, Clint Eastwood and Helen Mirren were among the multiple nominees, while the ensemble drama "Babel" led contenders with seven nominations, including best dramatic picture and supporting-acting honors for Brad Pitt.
Martin Scorsese's mob movie "The Departed" was next with six nominations, including best drama and best actor for DiCaprio, who had a second lead-actor nomination for the African adventure "Blood Diamond." Jack Nicholson and Mark Wahlberg also received acting nods for "The Departed."
The musical "Dreamgirls" looked like a favorite to win the best musical or comedy Globe, though Sacha Baron Cohen's raucous satire of American culture "Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan" was also a strong contender.
"Borat," an unexpected $100 million hit, also scored Cohen a nod for best actor in a musical or comedy.
Mirren was the clear favorite for best dramatic actress as Elizabeth II in "The Queen." Forest Whitaker was heavily favored for dramatic actor as Ugandan dictator Idi Amin in "The Last King of Scotland."
Some intriguing choices cropped up among nominees for this year's Globes, Hollywood's second-biggest film honors after the Academy Awards and traditionally a solid forecast for how the Oscars might play out.
Previously, no actor or director had been nominated twice in the same category in one year. This time, the Globes set up intriguing competitions for actors and filmmakers competing against themselves.
Among them, Eastwood is up against himself as best director for his World War II epics "Flags of Our Fathers" and "Letters From Iwo Jima," which tell the story of the Pacific island battle from the American and Japanese points of view, respectively.
Academy Awards contenders can solidify their prospects with a win at the Globes. All four winners of the 2005 acting Oscars -- Reese Witherspoon, Philip Seymour Hoffman, Rachel Weisz and George Clooney -- preceded their wins with triumphs at the Globes.
But the Globes failed to predict the best-picture Oscar winner the last two years. "The Aviator" won best drama at the Globes for 2004 while "Million Dollar Baby" took the Oscar, and "Brokeback Mountain" won best drama at the Globes for last year, while "Crash" was the Oscar champ.
For the first time, the Golden Globes have an award for best animated feature film, following the lead of the Oscars, which added an animation category in 2001.
Globe animated nominees were the talking-automobiles comedy "Cars," the penguin romp "Happy Feet" and the fright flick "Monster House."
The Globes feature 13 categories for film and 11 for television. Warren Beatty will receive the Globes' Cecil B. DeMille Award for lifetime achievement.
The Hollywood Foreign Press Association, which awards the Globes, has roughly 85 members, while about 5,800 film professionals are eligible to vote for the Oscars.
Nominations for the Oscars closed Saturday, so the outcome of the Globes cannot affect who gets nominated.
The Associated Press contributed to this report.