Sea Urchin Genes Could Lead to Medical Breakthroughs

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Published November 09, 2006

| Live Science

Meet your new evolutionary cousin, the sea urchin.

By analyzing the newly sequenced genome of the spineless creature, an international team of scientists found just how much we have in common with it.

The research could lead to new drugs for human ills.

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"The sea urchin is surprisingly similar to humans," said George Weinstock of Baylor College of Medicine and co-director of the sea urchin-sequencing project. "Sea urchins don't look any more like humans than fruit flies, but about 70 percent of sea urchin genes have a human counterpart, whereas only about 40 percent of fruit fly genes do."

In a special report detailed in the Nov. 9 issue of the journal Science, research teams describe the genome of the purple sea urchin, revealing not only human-urchin similarities but also features such as the urchin's immune system, which far surpasses that of humans.

Spineless relatives

A sea urchin's pincushion look comes from a round inner shell, which is covered with spikes for spearing food and tiny tube feet used for creeping along the seafloor.

They belong to the phylum Echinodermata, which includes starfish and sea cucumbers, whereas humans belong to the phylum Chordata, or all animals with dorsal nerve cords.

Both the echinoderms and chordates belong to a larger group — a superphylum — called the deuterostomes, based on shared traits of embryonic development.

It's this relationship that has drawn so much scientific interest, as sea urchins can serve as a model for understanding how the two phyla, which are assumed to have common ancestry, split off and evolved different traits.

For the genome project, scientists collected DNA from the sperm of a male California purple sea urchin (Strongylocentrotus purpuratus), a species found along the west coast of the United States from Baja California to Alaska.

After identifying 23,300 genes made from 814 million letters of DNA code taken from the California purple sea urchin, the team of scientists found that 7,077 of them were also found in humans.

Long-lived

Analysis of the sea urchin genome — the first-ever non-chordate to be sequenced — revealed a surprisingly unique and complex immune system, which could explain sea urchins' lengthy life spans of up to 100 years.

"They live as long as we do, maybe longer, and thus must protect themselves," Weinstock told LiveScience. "So an elaborate set of defense genes would be necessary. What was absolutely unexpected was the finding that they had expanded the innate immunity branch of the immune system."

Humans have an acquired immune system, in which our body must learn how to attach and destroy invaders once they enter the body. Sea urchins, on the other hand, are hard-wired to detect foreign bacteria and viruses and begin an attack.

This rich toolbox of sea urchin genes could lead to new drugs for combating infectious diseases.

In fact, sea urchins carry genes associated with many human diseases, including muscular dystrophy and Huntington's disease

Urchin senses

The sequence also helped scientists uncover complexities belied by the urchin's simple exterior.

Sea urchins lack eyes and ears, but they sport genes associated with taste, vision, smell, hearing and balance, the study found.

"Nobody would have predicted that sea urchins have such a robust gene set for visual perception," said Gary Wessel of Brown University, a member of the Sea Urchin Genome Sequencing Consortium.

Some of the visual sensory proteins are clustered on appendage known as tube feet, the tiny white projections found on the bottom of starfish arms and down the sides of sea urchins.

The proteins are thought to aid processing of sensory information.

"It is remarkable that the same sensory proteins are used in organs with such different structures in sea urchins and man," Weinstock said.

It's not clear, however, how the spindly creatures use the vision proteins.

"There is not a lot of light at the bottom of the ocean, so it is not clear what they might be 'seeing,'" Weinstock said. "This is certainly an area that will be studied intensively as a result of the genome project."

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