The statement gave no details about why the 93-year-old former chief executive went to the clinic in Rochester, about 75 miles southeast of Minneapolis.
"No further releases or updates are anticipated prior to early next week," said the statement issued from Ford's office in Beaver Creek, Colo. Ford also has a home in Rancho Mirage, Calif.
Mayo Clinic spokesman John Murphy confirmed the statement but said he had no additional information.
A message seeking comment from Ford's chief of staff, Penny Circle, was not immediately returned.
Last month, Ford spent a few days in Colorado's Vail Valley Medical Center because of shortness of breath. In January, he was hospitalized for 12 days in Rancho Mirage for treatment of pneumonia.
Ford suffered two small strokes five years ago and spent about a week in a hospital.
He became the nation's oldest living former president after the death of Ronald Reagan in 2004.
Ford was House minority leader when President Nixon chose him to replace the resigned Spiro Agnew as vice president in 1973. Ford became president on Aug. 9, 1974, when Nixon resigned amid the Watergate scandal.