Judy Katz, the actor's publicist, called the story by the tabloid Sun "totally untrue."
Katz said Hasselhoff had not been drinking, but felt unwell after taking some medication for a recent arm injury and wasn't able to get on a flight Wednesday from Heathrow Airport to Los Angeles.
The Sun reported the actor had been told he could not board the flight because he was drunk. Witnesses told the newspaper Hasselhoff appeared to have trouble standing and told staff he was upset about his divorce from Pamela Bach. The divorce was finalized Wednesday in a Los Angeles court.
Hasselhoff, 54, was allowed to get on a later flight, the newspaper said.
The airline said only that a male passenger had been refused boarding after he was deemed unfit to travel.
"They gave him some strong antibiotics and he got sick at the airport," Katz said. "He couldn't get on the plane. It was his choice. He got on the later flight."
Last month, the actor sliced four tendons and an artery in a shaving accident at his London hotel.
Earlier this month, there were press reports that an intoxicated Hasselhoff had to be removed from the All England Club, which presents the Wimbledon tennis championships. He denied the claim.
Hasselhoff filed for divorce from Bach on Jan. 12 after 16 years of marriage, citing irreconcilable differences. Bach, 42, filed her own divorce papers, also citing irreconcilable differences.
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