A two-hour special will be taped this summer at Wembley Stadium in London and shown in November on NBC.
"Madonna is one of the greatest artists of our time and never fails to generate excitement," NBC Entertainment President Kevin Reilly said Friday. "We think this is going to be a big event for television."
The network is billing Madonna's special as the first-ever broadcast network performance by the Grammy-winning singer.
The special will feature songs from Madonna's latest album, "Confessions on a Dance Floor," along with some of her greatest hits.
Her tour, which opened May 21 in the Los Angeles area, is scheduled through early September, with stops including Chicago, Montreal, New York, Boston, Rome and Paris.