Arquette, 38, and Jane wed Sunday "surrounded by family and friends," publicist Jennifer Solari said.
Engaged since 2002, the two have a daughter, 3-year-old Harlow. Arquette, formerly married to Nicolas Cage, also has a 17-year-old son, Enzo, from her relationship with musician Paul Rossi.
Arquette won an Emmy last year for her role in "Medium" as a murder-solving psychic who communicates with the dead.
Jane's film roles include 2004's "The Punisher" and 1999's "Magnolia," as well as the TV movie "61 ," playing Mickey Mantle.