Moss, 32, appears in a white lace trench coat at the center of Burberry's main autumn-winter 2006-2007 ad, one in a series launched Monday to celebrate the company's 150th anniversary.
The black-and-white ads, shot against London cityscapes by Mario Testino, feature British cultural icons and their offspring, including 1960s model Penelope Tree and actor Max Irons, son of Jeremy Irons.
Burberry distanced itself from Moss in September, after The Daily Mirror published pictures of her allegedly using cocaine. The company dropped plans for her to appear in its fall 2005 campaign, and posters featuring Moss were removed from its flagship store.
Earlier this month, British prosecutors announced that Moss would not be charged over the tabloid claims, saying there was insufficient evidence.
Although Moss also lost contracts with Chanel, H&M and Gloria Vanderbilt after the photos were published, her career seems to have suffered no lasting damage.
After apologizing to "all the people I have let down" and visiting a rehab clinic in Arizona, she signed new modeling contracts and appeared on several magazine covers.
Burberry stressed in November that it had not severed ties with Moss.