The suit, which seeks unspecified damages, was filed Tuesday in Superior Court.
The suit says Voorhies, whom it describes as a "famous and popular actress," lost several "potential acting and hosting jobs" after the tabloid published a June 2005 article that said she was hospitalized for a cocaine addiction.
Her doctor wrote a letter confirming that she had no addiction and was not hospitalized for drug abuse, the suit said.
The tabloid story was "patently false and heinous," and humiliated her, the actress stated in her lawsuit, which alleges libel, invasion of privacy, unauthorized use of her image, name or voice and other claims.
Voorhies could not be located by The Associated Press for comment. A call to National Enquirer after hours Wednesday was not immediately returned.