The concert, dubbed "Bring 'Em Home Now!" will be held at the Hammerstein Ballroom on March 20, the 3rd anniversary of the invasion of Iraq. Rufus Wainwright and Bright Eyes will also perform, it was announced Wednesday.
Sheehan, who camped outside President Bush's ranch in Texas last year to protest the Iraq war, will speak during the concert. Her 24-year-old son, Casey, was killed in Iraq in 2004.
Chuck D, Fischerspooner, Peaches, Steve Earle and Devendra Banhart are also scheduled to perform.
"It is impossible not react to the current state of affairs through personal action and artistic production," said Casey Spooner of Fischerspooner in a statement.
Organizers said the concert will be followed by a national "Bring 'Em Home Now!" speaking tour that will feature Sheehan and various authors traveling to 15 U.S. cities in April.
More concert performers are expected to be added later.