Watch "The Big Story Weekend" Saturday and Sunday at 5 p.m. ET!

Saturday, January 14

Andrea Yates, the Texas woman who drowned five of her children in a bathtub, pleaded not guilty by reason of insanity earlier this week. Yates original conviction of life in prison was overturned. Andrea Yates' ex-husband, Russell Yates, speaks out! You won't want to miss it!

Then, Iran threatens to block inspections of its nuclear sites if confronted by the U.N. Security Council over its atomic activities. Steve Forbes, president and CEO of Forbes Inc., weighs in on the financial fallout.

And, Samuel Alito's weeklong confirmation hearings are over, but has the political fight just begun? Will Democrats give the Supreme Court nominee an up-or-down vote? We'll get a fair and balanced debate from Democratic strategist Laura Schwartz and Sandy Rios, president of Culture Campaign.

Sunday, January 15

We'll get an update on the West Virginia mine tragedy from Gov. Joe Manchin.

Plus, will Democrats filibuster Alito's confirmation? FOX News Supreme Court analyst Tim O'Brien weighs in.

Real journalism: fair and balanced. That's why we're No. 1 — FOX News Channel.