Talk show host Ellen DeGeneres and TV star Jennifer Garner also won multiple awards. Garner, of TV's "Alias" and the action movie "Elektra," got the nod for female action star and female TV star.
DeGeneres was honored as favorite daytime talk show host and funny female star, the same awards she took home last year.
Johnny Depp again was named favorite male movie star, although Sandra Bullock took female honors over Angelina Jolie and Nicole Kidman. Last year's winner, Julia Roberts, wasn't in the running.
Brad Pitt returned as favorite leading man.
On TV, the favorites included "CSI: Crime Scene Investigation," "American Idol" and "Extreme Makeover: Home Edition" -- all repeats.
"My Name is Earl" was named favorite new TV comedy and "Prison Break" won for favorite new TV drama after votes cast over the Internet during the live telecast were counted.
The People's Choice Awards were presented at the Shrine Auditorium and broadcast live on CBS.
The nominations were determined by editors at Entertainment Weekly, the People's Choice production team and a panel of pop culture fans. Winners were determined by Internet voting.
The complete list of favorites:
-- Female movie star: Sandra Bullock.
-- Male movie star: Johnny Depp.
-- Leading lady: Reese Witherspoon.
-- Leading man: Brad Pitt.
-- Female action star: Jennifer Garner.
-- Male action star: Matthew McConaughey.
-- On-screen matchup: Vince Vaughn & Owen Wilson (in "Wedding Crashers").
-- Movie comedy: "Wedding Crashers."
-- Movie drama: "Star Wars: Episode III: Revenge of the Sith."
-- Family movie: "Charlie and the Chocolate Factory."
-- Movie: "Star Wars: Episode III: Revenge of the Sith."
-- Female performer: Kelly Clarkson.
-- Male performer: Tim McGraw.
-- Group: Green Day.
-- Tour: U2.
-- Song From a Movie: "These Boots Are Made For Walkin'," as performed by Jessica Simpson in "The Dukes of Hazzard."
-- New TV comedy: "My Name is Earl."
-- New TV drama: "Prison Break."
-- Comedy: "Everybody Loves Raymond."
-- Drama: "CSI: Crime Scene Investigation."
-- Reality show, competition: "American Idol."
-- Reality show, other: "Extreme Makeover: Home Edition."
-- Late night talk show host: Jay Leno.
-- Daytime talk show host: Ellen DeGeneres.
-- Female TV star: Jennifer Garner.
-- Male TV star: Ray Romano.
-- Funny female star: Ellen DeGeneres.
-- Funny male star: Adam Sandler.
-- Crest Whitestrips Fans Favorite Smile: Cameron Diaz.
-- Nice 'N Easy Fans Favorite Hair: Faith Hill.
-- Olay Total Effects Fans Favorite Look: Jennifer Aniston.