"Yes, that's true. They have been separated for four years and it's amicable," Bertinelli spokeswoman Heidi Schaeffer told The Associated Press. She said the actress would have no further comment.
A divorce petition that Bertinelli, 45, filed in Los Angeles Superior Court Tuesday cited irreconcilable differences.
The couple wed on April 11, 1981, and have one son, 14-year-old Wolfgang Van Halen. According to the petition, they separated on Oct. 15, 2001.
Bertinelli shot to fame as the sexy 15-year-old daughter of Bonnie Franklin on the hit television show "One Day at a Time," which aired from 1975 to 1984. She rejoined Franklin and Mackenzie Phillips, who played her sister, for a reunion show earlier this year. She was also a regular on television's "Touched by an Angel" from 2001 to 2003.
Van Halen, 50, is one of the most celebrated lead guitarists in rock music. He rose to fame in the late 1970s, along with his brother, drummer Alex Van Halen, vocalist David Lee Roth and bassist Michael Anthony as members of Van Halen.
The group was known for wild excess both on and offstage in its early years, and Van Halen, once a heavy smoker, was treated for cancer in 2000 and 2001.