"The first thing that went through my mind was I was concerned for her, hoping that she was OK and that she and her baby were OK," said Depp, 42, who dated the supermodel for four years until 1998.
"No. 2 was just being appalled and shocked at the kind of vicious attacks," Depp said in an interview Friday with a British morning TV show.
"She's super sharp, really smart and (has) got a great heart. She's a good mum, and she just happens to be human, and the press wouldn't allow that, and that's unforgivable."
Moss, 31, recently left a U.S. rehab clinic and was reunited with her 3-year-old daughter, Lila Grace.
Moss lost several modeling contracts after the photographs were published, but her career appears to be back on track: she appears on the cover of this month's "Vanity Fair" magazine and recently shot a new campaign for designer Roberto Cavalli.