"The Prince of Darkness" was invited to perform at the annual Royal Variety Performance in Cardiff, Wales, on Nov. 21, Osbourne's spokesman, Lathum Nelson, said Tuesday.
Osbourne, 56, will join an international slate of entertainers that includes Andrea Bocelli and the Blue Man Group. His wife, Sharon, will also participate.
This is the second time Osbourne has been invited to take part in the Royal Variety Performance. A scheduling conflict prevented him from attending in 2004, he said in a statement.
"I cannot turn down this incredible honor twice," Osbourne said.
Osbourne, whose latest album, "Under Cover," was released Nov. 1, had been scheduled to appear at the Video Game Awards in Los Angeles on Nov. 18. The show will air Dec. 10.