"It wouldn't have surprised me if she had tried to commit suicide the week that everything hit the papers," Williams told reporters at a news conference to introduce his new album, "Intensive Care."
He said she was being singled out by the news media, which "have got a lot to answer for. We're talking about a woman who has never harmed anyone or hurt anyone and who has never pretended to be anyone she isn't."
"She's done nothing wrong. What she does in her private life should be her private life," Williams said. "She is an absolute icon, she's beautiful. Every time I have met her she has been really lovely to me."
Photos of Moss, 31, apparently snorting cocaine in a London music studio were published in the Daily Mirror tabloid last month. Soon after she lost contracts with H&M (search), Burberry and Chanel.
British newspapers reported last week that Moss checked into the Meadows rehab clinic (search) outside Phoenix, Ariz.