Trump will tape his appearance Friday for an episode set to air Oct. 24, the network said Wednesday.
"I'm thrilled that Donald Trump will be guest starring on `Days of Our Lives,'" Sheraton Kalouria, senior vice president, NBC Daytime, said in a statement.
"(Trump) intimately knows drama from his many business ventures to his weekly boardrooms on `The Apprentice.' Little does he know that the drama on `Days of Our Lives' is often more intense!"
The new season of "The Apprentice," in which candidates compete for a job with the real estate mogul, premieres Sept. 22.