Watch "The Big Story Weekend" Saturday and Sunday at 9 p.m ET

Saturday, August 20

A man who claims he saw Joran van der Sloot (search) and the Kalpoe brothers around 2:30 a.m. the night Natalee Holloway disappeared testified in an Aruban court this past week. His account is significant because Joran told authorities he was already home at 2:30 a.m. the night Natalee vanished. So is this man's testimony credible? And what does it mean for the case? We'll get the latest from Natalee's mother, Beth Holloway Twitty, Jossy Mansur, editor-in-chief of El Diario, and Aruban attorney Arlene Ellis-Schipper.

Then, forensic pathologist Dr. Michael Baden and former LAPD detective Mark Fuhrman weigh in on the investigation.

Pregnant Missouri woman Amanda Jones (search) has been missing since Sunday. Her last known encounter was with the alleged father of her unborn child. Is foul play involved? We'll get an update on the desperate search for Amanda from her parents, Hubert and Bertha Propst.

And BTK serial killer Dennis Rader (search) is sentenced to life in prison without parole. Was justice served?

Plus, we'll talk with Dr. Keith Ablow, author of "Inside the Mind of Scott Peterson."

Sunday, August 21

We'll go back to Aruba for more on the disappearance of Natalee Holloway. We'll get the latest from:

Jug Twitty, Natalee's stepfather
Tito Lacle, investigative reporter for Aruba Today
Chris Lejeuz, Aruban attorney
Art Wood, former Secret Service/participating in the search for Natalee

Then, John Couey, the man who murdered Jessica Lunsford (search), contacts FOX's Bill O'Reilly in a chilling letter. What did he say? We'll get the lowdown from Bill himself. You don't want to miss it.

And, no new information has surfaced in the case of missing Philadelphia mom LaToyia Figueroa (search). Is the likelihood of LaToyia's safe return dwindling? Simone Weichelbaum of the Philadelphia Daily News and Michael Coard, the attorney for the father of LaToyia's unborn child, weigh in.

Real journalism: fair and balanced. That's why we're No. 1 — FOX News Channel.