Watch "Hannity & Colmes" weeknights at 9 p.m. ET!

Here's just some of what we've got planned for you on a special edition of "Hannity & Colmes" tonight!

Wednesday, July 27

The search for Natalee Holloway (search) continues. As Aruban authorities seek to solve the case, the FBI is brought in and a million dollar reward is offered. But will it make a difference? Natalee's aunt, Linda Allison, speaks out.

Then, why are some conservatives concerned by Judge John Roberts' (search) nomination? "How To Talk To A Liberal" author Ann Coulter and radio talk show host Michael Reagan bring the heat to the debate!

Plus, recognize any of these children's names? Samantha Runnion (search). Elizabeth Smart (search). Jessica Lunsford (search). Dylan Groene (search). All were abducted from their homes by strangers who prey on the young. Their stories prove it can happen to anyone, anywhere, anytime. Missing persons expert John Walsh and "Baby Einstein" founder Julie Clark talk to Sean and Alan tonight about keeping our kids safe. It's an important interview you don't want to miss.

Also, we'll bring you the story of infants Nicholas and Nathaniel Draper (search), who are desperately awaiting heart transplants. Without replacement hearts, the two-week-old twins aren't likely to live for more than a year because of a rare heart condition. UCLA pediatric surgeons say that if they receive donor hearts, they could perform what may be the first heart transplant on twin newborn infants. It's a story of hope and survival that you'll see only on "Hannity & Colmes."

These stories and much more... Don't miss YOUR chance to join the debate tonight!

Real journalism: fair and balanced. That's why we're No. 1 — FOX News Channel.

About the Show

Fast-paced and hard-hitting, "Hannity & Colmes" brings viewers a heated discussion in a nightly face-off. Relishing in controversial topics, personalities and social issues, conservative radio commentator Sean Hannity and liberal radio personality Alan Colmes offer their points-of-view in an often animated, always compelling debate.

But, unlike similar debate shows — which often appear scripted — "Hannity & Colmes" conducts a live, spur of the moment deliberation on politics and social topics. Also, differentiating the show is its dedication to "move away from the Beltway," bringing audiences an alternative discussion program without the "in" comments.

Adding fuel to the fire, several high-profile guests have joined the program on a wide-range of topics.

"With guests who are 'in the middle of the fight,' we're able to hear their point-of-view on the topics, as well as advance our own feelings," said Hannity.

"Believe it or not, I agree with that statement," quipped Colmes.