The daily one-hour show will originate from Los Angeles. It is set for a fall 2006 debut, it was announced Tuesday.
"Megan is a fantastic performer. A great actor and a great communicator, as all of her fans know," Jeff Zucker, president of NBC (search) Universal Television Group, said in a statement. "Those skills will make her a great new addition to the daytime playing field."
Mullally won an Emmy Award in 2000 for her role as Karen Walker on NBC's "Will & Grace."
"I think it will be fun," the 46-year-old actress said of the talk show. "Jeff Zucker is going to play drums in the band."