"I'm very confident," Brown told "Access Hollywood" in an interview Tuesday night. "She's my lady and she's doing wonderful. Everything about her spirit right now is just great ... we're enjoying life again."
In March, Houston checked herself into a rehabilitation center for the second time in a year. Houston, who had said she was using the power of prayer to get over drugs, married Brown in 1992.
Brown, who has a history of drug and alcohol arrests, told "Access Hollywood" that it's been difficult for both of them.
"It's a team effort whenever somebody is ill," he said. "It takes two to make things work, so I have to be there for her just like she was there for me when I went through my rehab stint."
The 41-year-old Houston has been working on a comeback album.
"She's going to start recording," Brown said. "Hopefully, I will get to work with her on this album."
Brown, 36, is the subject of a new eight-episode reality TV show, "Being Bobby Brown (search)," set to debut June 30 on Bravo. The show will also feature Houston.