Dr. Phil McGraw will "confront O'Brien about the incidents that led up to his stay in the recovery program, the issues he faced while in treatment and the stories about his personal life that made headline news," CBS said Friday.
The hour-long special will air Wednesday at 8 p.m. EDT.
O'Brien, host of "The Insider" syndicated entertainment newsmagazine, is expected back at work Thursday after undergoing treatment in an alcohol rehabilitation program. He exited the program April 24.
A recording of obscene phone messages (search) left by what sounds like O'Brien's voice hurtled around the Internet while he was gone and became frequent water cooler talk.
O'Brien will talk about how he will deal with his colleagues when he returns to work and how to approach life without alcohol, CBS said.
He'll also appear May 5 on the syndicated "Dr. Phil" talk show.