They were married Saturday during a seaside ceremony at the Casa del Mar Hotel in Santa Monica, Bush's publicist, Sarah Fuller, said Monday.
Bush, 22, and Murray, 23, met in 2003 while filming "One Tree Hill," in which she plays feisty cheerleader Brooke Davis and Murray plays Lucas Scott, a brooding intellectual struggling to find peace.
They were engaged in July 2004. Murray said he proposed while they were in Australia, where he was finishing work on the movie "House of Wax."
"I had a bunch of roses and I put lights down on a tennis court that spelled something out for her," he said at the time, declining to say what the message read.
"House of Wax" debuts May 6. Bush stars in this summer's "Supercross."