Watch "The Big Story" weekdays at 5 p.m. ET

The largest attack on U.S. soil, September 11, 2001, launched a do-or-die campaign on terrorism. But now the U.N.'s Commission on Human Rights is calling the War on Terror a "defamation campaign" against Muslims. Is this a valid claim? We'll ask Walid Phares, academic chairman of the Coalition for Human Rights and terrorism analyst at Florida Atlantic University.

Plus, legally, felons aren't allowed to buy guns. But people on the "terror watch list" can and the Justice Department can't do anything about it. What, if anything, can be done to stop suspected terrorists from buying firearms in this country? FOX News' Heather Nauert gets the lowdown from Paul Rosenzweig, senior legal research fellow at the Heritage Foundation.

Then, scientists around the world scramble to destroy samples a of deadly flu strain sent to 5,000 labs. So could these samples cause a worldwide flu outbreak? John Barry, author of "The Great Influenza," gives us the lowdown.

And, if a new bill is passed, convicted prostitutes in Oregon could become licensed schoolteachers. But would you want a member of the oldest profession in the world teaching your children? Sue Comfort, a case manager at the Sponsors Women's Transition Program, responds.

Real journalism: fair and balanced. That's why we're No. 1 — FOX News Channel.

About the Show

Veteran newscaster John Gibson gets to the core of the most salient issues facing America today as host of FNC's hard-hitting primetime show "The Big Story with John Gibson."

Airing Monday through Friday at 5 p.m. ET, "The Big Story" gives you expert legal analysis from Judge Andrew Napolitano and in-depth interviews and reports from correspondent Heather Nauert.

"The Big Story with John Gibson" is one of the reasons that FOX News Channel is the most watched news network in daytime.

Note: All guests and topics subject to change