"There is always going to be the tough and the nasty. You just tune out to that," said Aniston in an interview on "Access Hollywood" to air Monday. Excerpts were released in advance.
Aniston and Pitt, who were married on July 29, 2000, announced their separation in January, after months of tabloid speculation that their marriage was in trouble.
The 36-year-old actress said that despite being on the receiving end of some negative headlines over the past year, she feels the public is rooting for her.
"There has been so much love and support," said Aniston, who starred in NBC's "Friends." "It feels real good."
Aniston also said she doesn't feel like she's made the full transition from television to film actress. "I feel like I have got one good foot in there, and we will see if they still want to have me back," she said. "I've just got to keep making good movies."
Her screen credits include "The Good Girl," "Bruce Almighty," "Along Came Polly" and the upcoming "Derailed," with Clive Owen.